Biology runs continuously.
Your experiments should too.
Keystone™ is a benchtop system for multi-day biology - designed to keep culture, interventions, and imaging in one uninterrupted run from setup to readout.
Your protocol is only as good as your worst handoff.
AI has made it faster to ask the question. It hasn't made it easier to trust the answer. Every transfer introduces a variable. Every overnight gap is an uncontrolled condition. Multi-day biology is compromised not by the science, but by the infrastructure around it.
The result is data you can't trust, failures you can't attribute, and runs you have to repeat.
The learning loop breaks in execution.
A lot of expensive software was built on fragmented experimental data. We decided to fix the bottom of that stack.
The shift toward human-relevant models demands infrastructure to match.
New Approach Methodologies are redefining preclinical biology. Organoids self-organize over days; their structural maturation depends on environmental stability held constant from the first hour to the last frame. Spheroids develop heterogeneous populations whose drug response signatures only make sense when observed continuously - not reconstructed from disconnected endpoints. But only if the infrastructure running them doesn't introduce the noise they were designed to eliminate.
Brightfield reveals morphology as it develops. Fluorescence shows phenotypic change as it happens. Absorbance verifies metabolic activity - on the same timeline as every other event in the run. Keystone was designed for this biology. Not adapted to it.
WHAT CONTINUOUS BIOLOGY REQUIRES
Stable culture
Temperature and CO₂ drift the moment cells leave the incubator. Re-equilibration takes time cells don't have. In Keystone™, the environment never breaks.
Scheduled actions
Media exchange, dosing, and staining, executed automatically at defined timepoints, logged to the run. Timed to the biology, not the schedule.
Multimodal readout
An organoid can look perfect and do nothing. Confirming biological validity means measuring structure, function, and metabolic activity together.
The product is the run.
Keystone™ supports protocols where continuity is essential.
Where a gap in execution becomes a gap in the answer.
Longitudinal phenotyping
The same well, imaged continuously across days. Morphological progression, structural changes, and population dynamics - captured without environmental disruption between acquisitions.
Multi-step assay execution
Media exchange, dosing, staining, and imaging - sequenced automatically, logged to the run. Every intervention is an attributed event, not a gap in the data.
Drug response kinetics
Cytostatic and cytotoxic responses look identical at 72 hours. Continuous imaging resolves the kinetic difference - when the arrest began, how far it progressed, whether it recovered.
One run. One record.
Every Keystone™ run produces a traceable record: images, interventions, and readouts on one timeline, every result attributed to its exact conditions. The ground truth AI drug discovery has always needed.
From the first well
to the last frame.
Keystone™ integrates incubation, fluid handling, imaging,
and run control into a single benchtop system.
Cells stay in the same environment from seeding to final acquisition.
Every module runs on the same clock.
Incubation
Stable temperature, CO₂, and humidity from single-plate to multi-plate runs.
Fluidics
Programmable exchange schedules. Automated reagent delivery.
Imaging
Brightfield, fluorescence and absorbance. In-situ, non-destructive, timestamped.
Run control
Full event log. Every action timestamped, sequenced, and exportable.
Built around standard formats
96-well today. 384-well in development.
Designed for 2D and 3D assay formats, with room to expand.
Help build better experimental systems.
We're building instrumentation for biology that can't afford to lose continuity. The work spans hardware, software, and application science - and the best people here tend to care about all three.
Own subsystem integration across mechanics, fluid handling, motion, and imaging. Improve reliability, manufacturability, and test infrastructure for multi-day biological runs.
#mechatronics #system-integration #hardware #DFM #reliability #lab-automation
Work directly with pilot labs to adapt Keystone protocols to real biological workflows. You understand what multi-day cell culture actually requires, and you can translate that into automated run configurations that produce data worth trusting.
#cell-biology #organoids #assay-development #protocol-design #lab-automation
Tell us what you’re running.
We're working with a small number of labs whose protocols are limited by handoffs, timing drift, or fragile multi-day execution. If that sounds familiar, we'd like to talk.
Pilot partners work directly with the team to adapt Keystone™ to real workflows that need tighter execution, clearer records, and fewer manual gaps.
We'd rather go deep with fewer labs than spread thin across many.